Role of the 293b-sensitive, slowly activating delayed rectifier potassium current, iKs, in pacemaker activity of rabbit isolated sino-atrial node cells
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چکیده
منابع مشابه
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
We have investigated the physiological role of the "rapidly activating" delayed rectifier K+ current (IKr) in pacemaker activity in isolated sinoatrial node (SAN) myocytes and the expression of mouse ether-a-go-go (mERG) genes in the adult mouse SAN. In isolated, voltage-clamped SAN cells, outward currents evoked by depolarizing steps (greater than -40 mV) were strongly inhibited by the class I...
متن کاملSevoflurane inhibition of the slowly activating delayed rectifier K+ current in guinea pig ventricular cells.
Single ventricular cells were enzymatically isolated from guinea pig hearts and the effects of sevoflurane on the delayed rectifier K(+) current were investigated by the patch clamp method. The rapidly (I(Kr)) and slowly activating delayed rectifier K(+) current (I(Ks)) were isolated using chromanol 293B, a selective blocker for I(Ks) or E4031 (N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperid...
متن کاملPacemaker mechanism of porcine sino-atrial node cells.
In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
متن کاملA rapidly-activating delayed rectifier K current, IKr, regulates pacemaker activity in adult mouse sinoatrial node cells Short title: IKr regulates mouse cardiac pacemaker activity
Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, 3330 Hospital Drive, N.W., Calgary, Alberta, Canada T2N 4N1 *Laboratoire de Genomique Fonctionnelle CNRS UPR 2580 and Institut de Genetique Humaine, CNRS UPR 1142 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France Department of Internal Medicine, Karl-Franzens-University Hospital, Auenbruggerplatz 1...
متن کاملEffects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium
OBJECTIVE Allocryptopine (ALL) is an effective alkaloid of Corydalis decumbens (Thunb.) Pers. Papaveraceae and has proved to be anti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current (I to) and slow delayed rectifier potassium current (I Ks). METHODS The monophasic action potential (MAP) techniqu...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2002
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(01)00459-x